>Since a holon is embedded in larger wholes, it is influenced by and influences these larger wholes. And since a holon also contains subsystems, or parts, it is similarly influenced by and influences these parts. Information flows bidirectionally between smaller and larger systems as well as through rhizomatic contagion.
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When this bidirectionality of information flow and understanding of role is compromised, for whatever reason, the system begins to break down: wholes no longer recognize their dependence on their subsidiary parts, and parts no longer recognize the organizing authority of the wholes. Cancer may be understood as such a breakdown in the biological realm.
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A hierarchy of holons is called a holarchy. The holarchic model can be seen as an attempt to modify and modernise perceptions of natural hierarchy.
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wikipedia 